GDF2

Gene Information

Official Symbol: GDF2
Official Name: growth differentiation factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 2658
UniProt: Q9UK05
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016].
UniProt Summary: Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:21710321, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:25237187}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9168
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Etoposide 0.3μM R05 exp199	-1.76
Oligomycin-A 20μM R00 exp26	1.91

TGF beta
TGFb propeptide

pathway-restricted SMAD protein phosphorylation
positive regulation of endothelial cell differentiation
activin receptor signaling pathway
branching involved in blood vessel morphogenesis
negative regulation of blood vessel endothelial cell migration
positive regulation of BMP signaling pathway
positive regulation of cartilage development
regulation of endothelial cell differentiation
negative regulation of endothelial cell proliferation
negative regulation of DNA biosynthetic process
negative regulation of DNA replication
transforming growth factor beta receptor binding
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of endothelial cell migration
positive regulation of interleukin-8 production
SMAD protein signal transduction
positive regulation of epithelial cell differentiation
regulation of pathway-restricted SMAD protein phosphorylation
cellular iron ion homeostasis
negative regulation of epithelial cell migration
vasculogenesis
regulation of interleukin-8 production
regulation of cartilage development
iron ion homeostasis
cell
regulation of BMP signaling pathway
regulation of blood vessel endothelial cell migration
BMP signaling pathway
positive regulation of endothelial cell proliferation
negative regulation of angiogenesis
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
response to BMP
cellular response to BMP stimulus
negative regulation of blood vessel morphogenesis
cellular transition metal ion homeostasis
regulation of DNA replication
regulation of DNA biosynthetic process
negative regulation of vasculature development
negative regulation of DNA metabolic process
negative regulation of epithelial cell proliferation