GGA3 [The Human Chemical-Genetic Interaction Map Project]

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======= GGA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGA3
  * **<color #00a2e8>Official Name</color>**: golgi associated, gamma adaptin ear containing, ARF binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23163|23163]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ52|Q9NZ52]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606006|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. {ECO:0000269|PubMed:11301005}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHS|
|GAT|
|Alpha adaptinC2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ADP-ribosylation factor binding|
|negative regulation of amyloid-beta formation|
|negative regulation of amyloid precursor protein catabolic process|
|protein localization to cell surface|
|regulation of amyloid-beta formation|
|regulation of amyloid precursor protein catabolic process|
|Golgi to plasma membrane protein transport|
|endocytic recycling|
|protein localization to lysosome|
|protein destabilization|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|protein localization to vacuole|
|ubiquitin binding|
|recycling endosome membrane|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|negative regulation of cellular amide metabolic process|
|early endosome membrane|
|trans-Golgi network|
|protein localization to plasma membrane|
|endosome membrane|
|positive regulation of protein catabolic process|
|protein localization to cell periphery|
|endosomal transport|
|establishment of protein localization to membrane|
|regulation of protein stability|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|protein localization to membrane|
|protein localization to organelle|
|Golgi apparatus|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of protein metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.52|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.85|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.74|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.71|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.75|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.81|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.89|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.95|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.14|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.16|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|2.22|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pcf11|PCF11]]|0.465|
|[[:human genes:r:rbbp5|RBBP5]]|0.462|
|[[:human genes:i:iscu|ISCU]]|0.454|
|[[:human genes:p:pola2|POLA2]]|0.451|
|[[:human genes:p:polr2f|POLR2F]]|0.441|
|[[:human genes:p:psmd11|PSMD11]]|0.439|
|[[:human genes:r:rbm39|RBM39]]|0.43|
|[[:human genes:t:twistnb|TWISTNB]]|0.428|
|[[:human genes:r:rps12|RPS12]]|0.427|
|[[:human genes:s:sf3a1|SF3A1]]|0.423|
|[[:human genes:n:npipb5|NPIPB5]]|0.422|
|[[:human genes:p:psma6|PSMA6]]|0.421|
|[[:human genes:r:rps27a|RPS27A]]|0.421|
|[[:human genes:a:akirin2|AKIRIN2]]|0.42|
|[[:human genes:r:rps2|RPS2]]|0.419|
|[[:human genes:r:ranbp2|RANBP2]]|0.415|
|[[:human genes:g:golga8j|GOLGA8J]]|0.411|
|[[:human genes:p:psmb4|PSMB4]]|0.41|
|[[:human genes:r:rpl6|RPL6]]|0.41|
|[[:human genes:u:utp3|UTP3]]|0.409|
|[[:human genes:t:tspy8|TSPY8]]|0.409|
|[[:human genes:r:rpl15|RPL15]]|0.408|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.406|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.404|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.403|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.403|
|[[:human genes:f:fam86b2|FAM86B2]]|0.402|
|[[:human genes:n:nfatc4|NFATC4]]|0.402|
|[[:human genes:d:ddx56|DDX56]]|0.401|
|[[:human genes:c:cbwd5|CBWD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2182
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGA3 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>