GGA3

Official Symbol: GGA3
Official Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 23163
UniProt: Q9NZ52
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. {ECO:0000269|PubMed:11301005}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP-ribosylation factor binding
negative regulation of amyloid-beta formation
negative regulation of amyloid precursor protein catabolic process
protein localization to cell surface
regulation of amyloid-beta formation
regulation of amyloid precursor protein catabolic process
Golgi to plasma membrane protein transport
endocytic recycling
protein localization to lysosome
protein destabilization
establishment of protein localization to plasma membrane
Golgi to plasma membrane transport
protein localization to vacuole
ubiquitin binding
recycling endosome membrane
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
negative regulation of cellular amide metabolic process
early endosome membrane
trans-Golgi network
protein localization to plasma membrane
endosome membrane
positive regulation of protein catabolic process
protein localization to cell periphery
endosomal transport
establishment of protein localization to membrane
regulation of protein stability
Golgi vesicle transport
regulation of protein catabolic process
regulation of cellular amide metabolic process
positive regulation of catabolic process
protein localization to membrane
protein localization to organelle
Golgi apparatus
regulation of catabolic process
intracellular protein transport
negative regulation of protein metabolic process
protein transport
intracellular transport
peptide transport