GGH

Entrez Summary: This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008].
UniProt Summary: Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Peptidase C26
GATase

gamma-glutamyl-peptidase activity
tetrahydrofolylpolyglutamate metabolic process
omega peptidase activity
exopeptidase activity
vacuole
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
response to zinc ion
tertiary granule lumen
specific granule lumen
azurophil granule lumen
melanosome
response to ethanol
cellular modified amino acid metabolic process
response to insulin
response to alcohol
coenzyme metabolic process
response to antibiotic
response to metal ion
response to peptide hormone
cofactor metabolic process
response to peptide
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
response to toxic substance
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
response to inorganic substance
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
cellular amide metabolic process
exocytosis
carboxylic acid metabolic process