GGNBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= GGNBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GGNBP2
  * **<color #00a2e8>Official Name</color>**: gametogenetin binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79893|79893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3C7|Q9H3C7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GGNBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GGNBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612275|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in spermatogenesis.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of peptidyl-serine phosphorylation of STAT protein|
|negative regulation of tyrosine phosphorylation of STAT protein|
|labyrinthine layer blood vessel development|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation of STAT protein|
|negative regulation of peptidyl-serine phosphorylation|
|negative regulation of protein tyrosine kinase activity|
|placenta blood vessel development|
|labyrinthine layer development|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of tyrosine phosphorylation of STAT protein|
|embryonic placenta development|
|regulation of protein tyrosine kinase activity|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|regulation of peptidyl-serine phosphorylation|
|placenta development|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|cytoplasmic vesicle|
|negative regulation of transferase activity|
|in utero embryonic development|
|negative regulation of protein phosphorylation|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|negative regulation of phosphorylation|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|negative regulation of protein modification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|circulatory system development|
|regulation of kinase activity|
|regulation of transferase activity|
|embryo development|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.28|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.76|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.73|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:actr10|ACTR10]]|0.446|
|[[:human genes:d:dpagt1|DPAGT1]]|0.439|
|[[:human genes:m:med16|MED16]]|0.415|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4749
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GGNBP2 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>