GGNBP2
Gene Information
- Official Symbol: GGNBP2
- Official Name: gametogenetin binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 79893
- UniProt: Q9H3C7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in spermatogenesis.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of peptidyl-serine phosphorylation of STAT protein |
| negative regulation of tyrosine phosphorylation of STAT protein |
| labyrinthine layer blood vessel development |
| negative regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of receptor signaling pathway via STAT |
| regulation of peptidyl-serine phosphorylation of STAT protein |
| negative regulation of peptidyl-serine phosphorylation |
| negative regulation of protein tyrosine kinase activity |
| placenta blood vessel development |
| labyrinthine layer development |
| negative regulation of peptidyl-tyrosine phosphorylation |
| regulation of tyrosine phosphorylation of STAT protein |
| embryonic placenta development |
| regulation of protein tyrosine kinase activity |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| regulation of peptidyl-serine phosphorylation |
| placenta development |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| cytoplasmic vesicle |
| negative regulation of transferase activity |
| in utero embryonic development |
| negative regulation of protein phosphorylation |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| negative regulation of phosphorylation |
| blood vessel development |
| vasculature development |
| cardiovascular system development |
| spermatogenesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| male gamete generation |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| gamete generation |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| circulatory system development |
| regulation of kinase activity |
| regulation of transferase activity |
| embryo development |
| multi-organism reproductive process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.0125μM R03 exp97 | -2.28 |
| HMS-I2 10μM R06 exp288 | -2.01 |
| Colchicine 0.009μM R05 exp215 | -1.76 |
| Losmapimod 1μM R07 exp376 | -1.73 |
| TRAIL 50ng/ml R00 exp36 | 2.03 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 9/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 2/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4749
- Expression level (log2 read counts): 6.7
Expression Distribution
GGNBP2 Expression in NALM6 Cells: 6.7
