GGT1

Gene Information

Official Symbol: GGT1
Official Name: gamma-glutamyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 2678
UniProt: P19440
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014].
UniProt Summary: Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. {ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4197
Expression level (log2 read counts): 0.89

Expression Distribution

leukotriene-C(4) hydrolase
cysteine biosynthetic process
peptidyltransferase activity
hypoglycin A gamma-glutamyl transpeptidase activity
peptide modification
leukotriene C4 gamma-glutamyl transferase activity
glutathione hydrolase activity
glutathione catabolic process
leukotriene D4 metabolic process
leukotriene D4 biosynthetic process
cysteine metabolic process
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
serine family amino acid biosynthetic process
sulfur amino acid biosynthetic process
leukotriene biosynthetic process
peptide catabolic process
cellular modified amino acid catabolic process
glutamate metabolic process
leukotriene metabolic process
sulfur amino acid metabolic process
zymogen activation
serine family amino acid metabolic process
icosanoid biosynthetic process
cellular modified amino acid biosynthetic process
glutathione metabolic process
sulfur compound catabolic process
cofactor catabolic process
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
fatty acid derivative biosynthetic process
dicarboxylic acid metabolic process
icosanoid metabolic process
xenobiotic metabolic process
response to estradiol
protein processing
fatty acid derivative metabolic process
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus