GINS1

Entrez Summary: N/A
UniProt Summary: The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function. {ECO:0000269|PubMed:17417653}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 733/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	32/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

DNA strand elongation involved in cell cycle DNA replication
DNA strand elongation involved in mitotic DNA replication
DNA strand elongation involved in nuclear cell cycle DNA replication
GINS complex
mitotic DNA replication
inner cell mass cell proliferation
DNA strand elongation involved in DNA replication
blastocyst growth
3-5 DNA helicase activity
DNA strand elongation
nuclear DNA replication
cell cycle DNA replication
blastocyst development
DNA duplex unwinding
DNA geometric change
DNA-dependent DNA replication
DNA replication
DNA conformation change
in utero embryonic development
developmental growth
growth
cell population proliferation
mitotic cell cycle process
chordate embryonic development
embryo development ending in birth or egg hatching
mitotic cell cycle
DNA metabolic process
embryo development
cell cycle process
chromosome organization
cell cycle
cellular macromolecule biosynthetic process
macromolecule biosynthetic process