GIP [The Human Chemical-Genetic Interaction Map Project]

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======= GIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GIP
  * **<color #00a2e8>Official Name</color>**: gastric inhibitory polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2695|2695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09681|P09681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glucagon secretion|
|regulation of glucagon secretion|
|response to selenium ion|
|response to acidic pH|
|positive regulation of cAMP-mediated signaling|
|exploration behavior|
|triglyceride homeostasis|
|acylglycerol homeostasis|
|endocrine pancreas development|
|response to pH|
|positive regulation of glucose transmembrane transport|
|regulation of fatty acid biosynthetic process|
|long-term synaptic potentiation|
|regulation of cAMP-mediated signaling|
|response to axon injury|
|pancreas development|
|positive regulation of insulin secretion|
|regulation of glucose transmembrane transport|
|sensory perception of pain|
|adult locomotory behavior|
|regulation of fatty acid metabolic process|
|positive regulation of peptide hormone secretion|
|hormone activity|
|response to amino acid|
|secretory granule lumen|
|memory|
|endocrine system development|
|positive regulation of hormone secretion|
|lipid homeostasis|
|response to glucose|
|response to hexose|
|digestive system development|
|adult behavior|
|response to monosaccharide|
|positive regulation of synaptic transmission|
|regulation of cellular ketone metabolic process|
|response to carbohydrate|
|regulation of insulin secretion|
|female pregnancy|
|regulation of lipid biosynthetic process|
|regulation of synaptic plasticity|
|response to starvation|
|locomotory behavior|
|positive regulation of transmembrane transport|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|cognition|
|endoplasmic reticulum lumen|
|response to acid chemical|
|neuronal cell body|
|response to peptide hormone|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|response to peptide|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of hormone levels|
|regulation of transmembrane transport|
|behavior|
|response to wounding|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|sensory perception|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GIP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>