GIT1 [The Human Chemical-Genetic Interaction Map Project]

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======= GIT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GIT1
  * **<color #00a2e8>Official Name</color>**: GIT ArfGAP 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28964|28964]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2X7|Q9Y2X7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GIT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GIT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000269|PubMed:11896197}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GIT SHD|
|GIT1 C|
|Ank 2|
|ArfGap|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic modulation of chemical synaptic transmission|
|calyx of Held|
|regulation of synaptic vesicle exocytosis|
|ephrin receptor signaling pathway|
|regulation of cytokinesis|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of neurotransmitter transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of regulated secretory pathway|
|regulation of cell division|
|regulation of exocytosis|
|protein-containing complex binding|
|GTPase activator activity|
|regulation of neurotransmitter levels|
|positive regulation of GTPase activity|
|focal adhesion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of GTPase activity|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of vesicle-mediated transport|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of cellular localization|
|regulation of cell cycle|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.39|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.81|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.74|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.74|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10023
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GIT1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>