GIT1

Entrez Summary: N/A
UniProt Summary: GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity). {ECO:0000250|UniProtKB:Q68FF6, ECO:0000269|PubMed:11896197}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

presynaptic modulation of chemical synaptic transmission
calyx of Held
regulation of synaptic vesicle exocytosis
ephrin receptor signaling pathway
regulation of cytokinesis
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
regulation of G protein-coupled receptor signaling pathway
regulation of regulated secretory pathway
regulation of cell division
regulation of exocytosis
protein-containing complex binding
GTPase activator activity
regulation of neurotransmitter levels
positive regulation of GTPase activity
focal adhesion
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
regulation of GTPase activity
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of vesicle-mediated transport
enzyme linked receptor protein signaling pathway
regulation of secretion by cell
regulation of cell cycle process
positive regulation of hydrolase activity
regulation of secretion
regulation of cellular localization
regulation of cell cycle
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function
regulation of transport
membrane