GJA5

Gene Information

Official Symbol: GJA5
Official Name: gap junction protein alpha 5
Aliases and Previous Symbols: N/A
Entrez ID: 2702
UniProt: P36382
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10135
Expression level (log2 read counts): -4.27

Expression Distribution

Connexin CCC
Connexin

Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
vasomotion
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
atrial cardiac muscle cell to AV node cell communication by electrical coupling
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling
regulation of Purkinje myocyte action potential
bundle of His cell to Purkinje myocyte communication by electrical coupling
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling
atrial ventricular junction remodeling
positive regulation of cell communication by chemical coupling
regulation of bundle of His cell action potential
regulation of cell communication by chemical coupling
SA node cell to atrial cardiac muscle cell communication by electrical coupling
gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
foramen ovale closure
pulmonary valve formation
regulation of AV node cell action potential
cell communication by chemical coupling
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
gap junction channel activity involved in cardiac conduction electrical coupling
AV node cell to bundle of His cell communication by electrical coupling
negative regulation of glomerular filtration
regulation of renin secretion into blood stream
regulation of membrane depolarization during cardiac muscle cell action potential
connexin binding
septum primum development
gap junction hemi-channel activity
regulation of atrial cardiac muscle cell action potential
Purkinje myocyte to ventricular cardiac muscle cell communication
regulation of membrane depolarization during action potential
gap junction assembly
regulation of ventricular cardiac muscle cell membrane depolarization
regulation of atrial cardiac muscle cell membrane depolarization
SA node cell action potential
SA node cell to atrial cardiac muscle cell signaling
SA node cell to atrial cardiac muscle cell communication
mitral valve development
regulation of glomerular filtration
AV node cell to bundle of His cell communication
cardiac conduction system development