GK

Entrez Summary: The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
UniProt Summary: Key enzyme in the regulation of glycerol uptake and metabolism.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

FGGY C
FGGY N

glycerol kinase activity
glycerol-3-phosphate biosynthetic process
glycerol catabolic process
alditol catabolic process
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
triglyceride biosynthetic process
glycerol metabolic process
acylglycerol biosynthetic process
neutral lipid biosynthetic process
alditol metabolic process
polyol catabolic process
cellular carbohydrate catabolic process
alcohol catabolic process
triglyceride metabolic process
organic hydroxy compound catabolic process
acylglycerol metabolic process
neutral lipid metabolic process
polyol metabolic process
carbohydrate catabolic process
mitochondrial outer membrane
cellular carbohydrate metabolic process
glycerolipid biosynthetic process
alcohol metabolic process
glycerolipid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
carbohydrate metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
mitochondrion
phosphorylation
ATP binding
small molecule metabolic process
organic substance catabolic process