GLA [The Human Chemical-Genetic Interaction Map Project]

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======= GLA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLA
  * **<color #00a2e8>Official Name</color>**: galactosidase alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2717|2717]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06280|P06280]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Melibiase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|raffinose alpha-galactosidase activity|
|alpha-galactosidase activity|
|galactoside binding|
|glycosylceramide catabolic process|
|negative regulation of nitric-oxide synthase activity|
|glycoside catabolic process|
|negative regulation of monooxygenase activity|
|glycosphingolipid catabolic process|
|negative regulation of nitric oxide metabolic process|
|negative regulation of nitric oxide biosynthetic process|
|glycolipid catabolic process|
|glycosylceramide metabolic process|
|ceramide catabolic process|
|glycoside metabolic process|
|negative regulation of oxidoreductase activity|
|negative regulation of reactive oxygen species biosynthetic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|regulation of nitric-oxide synthase activity|
|glycosyl compound catabolic process|
|catalytic activity|
|oligosaccharide metabolic process|
|regulation of monooxygenase activity|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|glycosphingolipid metabolic process|
|hydrolase activity|
|ceramide metabolic process|
|regulation of reactive oxygen species biosynthetic process|
|azurophil granule lumen|
|lysosomal lumen|
|regulation of oxidoreductase activity|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|glycosyl compound metabolic process|
|sphingolipid metabolic process|
|regulation of reactive oxygen species metabolic process|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|lysosome|
|lipid catabolic process|
|signaling receptor binding|
|regulation of neurotransmitter levels|
|carbohydrate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|exocytosis|
|protein homodimerization activity|
|leukocyte activation|
|cellular lipid metabolic process|
|Golgi apparatus|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|secretion|
|negative regulation of molecular function|
|lipid metabolic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12657
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLA Expression in NALM6 Cells: 5.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>