GLA

Entrez Summary: This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

raffinose alpha-galactosidase activity
alpha-galactosidase activity
galactoside binding
glycosylceramide catabolic process
negative regulation of nitric-oxide synthase activity
glycoside catabolic process
negative regulation of monooxygenase activity
glycosphingolipid catabolic process
negative regulation of nitric oxide metabolic process
negative regulation of nitric oxide biosynthetic process
glycolipid catabolic process
glycosylceramide metabolic process
ceramide catabolic process
glycoside metabolic process
negative regulation of oxidoreductase activity
negative regulation of reactive oxygen species biosynthetic process
sphingolipid catabolic process
membrane lipid catabolic process
regulation of nitric-oxide synthase activity
glycosyl compound catabolic process
catalytic activity
oligosaccharide metabolic process
regulation of monooxygenase activity
negative regulation of reactive oxygen species metabolic process
regulation of nitric oxide biosynthetic process
glycosphingolipid metabolic process
hydrolase activity
ceramide metabolic process
regulation of reactive oxygen species biosynthetic process
azurophil granule lumen
lysosomal lumen
regulation of oxidoreductase activity
glycolipid metabolic process
liposaccharide metabolic process
glycosyl compound metabolic process
sphingolipid metabolic process
regulation of reactive oxygen species metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
membrane lipid metabolic process