GLB1

Entrez Summary: This gene encodes a member of the glycosyl hydrolase 35 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature lysosomal enzyme. This enzyme catalyzes the hydrolysis of a terminal beta-linked galactose residue from ganglioside substrates and other glycoconjugates. Mutations in this gene may result in GM1-gangliosidosis and Morquio B syndrome. [provided by RefSeq, Nov 2015].
UniProt Summary: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyco hydro 35
Glyco hydro 42

response to cortisone
response to Thyroglobulin triiodothyronine
beta-galactosidase activity
galactoside binding
galactose catabolic process
keratan sulfate catabolic process
galactose metabolic process
vacuole
keratan sulfate metabolic process
hexose catabolic process
sulfur compound catabolic process
glycosaminoglycan catabolic process
monosaccharide catabolic process
glycosphingolipid metabolic process
aminoglycan catabolic process
azurophil granule lumen
lysosomal lumen
mucopolysaccharide metabolic process
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate catabolic process
ficolin-1-rich granule lumen
response to glucocorticoid
sphingolipid metabolic process
glycosaminoglycan metabolic process
hexose metabolic process
response to corticosteroid
aminoglycan metabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
response to ketone
monosaccharide metabolic process
membrane lipid metabolic process
response to alcohol
response to steroid hormone
sulfur compound metabolic process
small molecule catabolic process
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response