GLDC

Entrez Summary: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010].
UniProt Summary: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). {ECO:0000269|PubMed:1993704, ECO:0000269|PubMed:1996985, ECO:0000269|PubMed:28244183}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GDC-P
Beta elim lyase

pyridoxal binding
glycine dehydrogenase (decarboxylating) activity
response to lipoic acid
response to methylamine
glycine cleavage complex
glycine decarboxylation via glycine cleavage system
glycine catabolic process
lyase activity
glycine binding
serine family amino acid catabolic process
glycine metabolic process
neurotransmitter catabolic process
serine family amino acid metabolic process
response to amine
pyridoxal phosphate binding
electron transfer activity
response to fatty acid
neurotransmitter metabolic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
alpha-amino acid catabolic process
cellular amino acid catabolic process
drug catabolic process
electron transport chain
response to ammonium ion
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
response to acid chemical
enzyme binding
regulation of neurotransmitter levels
mitochondrial matrix
generation of precursor metabolites and energy
small molecule catabolic process
drug metabolic process
response to lipid
protein homodimerization activity
carboxylic acid metabolic process
response to organic cyclic compound