GLI1

Gene Information

Official Symbol: GLI1
Official Name: GLI family zinc finger 1
Aliases and Previous Symbols: N/A
Entrez ID: 2735
UniProt: P08151
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
UniProt Summary: Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'- GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:8378770, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4909
Expression level (log2 read counts): 1.05

Expression Distribution

notochord regression
ventral midline development
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
positive regulation of cerebellar granule cell precursor proliferation
regulation of cerebellar granule cell precursor proliferation
notochord morphogenesis
anatomical structure regression
regulation of hepatocyte proliferation
notochord development
positive regulation of cardiac muscle cell proliferation
cerebellar cortex morphogenesis
liver regeneration
proximal/distal pattern formation
positive regulation of smoothened signaling pathway
positive regulation of cardiac muscle tissue growth
ciliary base
positive regulation of DNA replication
positive regulation of heart growth
cerebellum morphogenesis
regulation of cardiac muscle cell proliferation
hindbrain morphogenesis
prostate gland development
pituitary gland development
positive regulation of cardiac muscle tissue development
ciliary tip
cerebellar cortex development
positive regulation of cell cycle G1/S phase transition
positive regulation of organ growth
digestive tract morphogenesis
positive regulation of neural precursor cell proliferation
regulation of cardiac muscle tissue growth
regulation of heart growth
positive regulation of muscle organ development
positive regulation of striated muscle tissue development
positive regulation of muscle tissue development
smoothened signaling pathway
animal organ regeneration
diencephalon development
regulation of smoothened signaling pathway