GLI2

Gene Information

Official Symbol: GLI2
Official Name: GLI family zinc finger 2
Aliases and Previous Symbols: N/A
Entrez ID: 2736
UniProt: P10070
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].
UniProt Summary: Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}. Isoform 5: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6265
Expression level (log2 read counts): 0.56

Expression Distribution

floor plate formation
notochord regression
floor plate morphogenesis
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
spinal cord ventral commissure morphogenesis
smoothened signaling pathway involved in ventral spinal cord interneuron specification
ventral midline development
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
prostatic bud formation
smoothened signaling pathway involved in ventral spinal cord patterning
cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
morphogenesis of an epithelial bud
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
floor plate development
hindgut morphogenesis
positive regulation of cerebellar granule cell precursor proliferation
hindgut development
lateral sprouting from an epithelium
regulation of cerebellar granule cell precursor proliferation
notochord morphogenesis
anatomical structure regression
cell fate specification involved in pattern specification
ventral spinal cord interneuron specification
positive regulation of T cell differentiation in thymus
spinal cord motor neuron cell fate specification
cell fate commitment involved in pattern specification
ventral spinal cord interneuron fate commitment
ventral spinal cord interneuron differentiation
dorsal/ventral neural tube patterning
morphogenesis of an epithelial fold
osteoblast development
notochord development
spinal cord dorsal/ventral patterning
negative regulation of chondrocyte differentiation
prostate gland epithelium morphogenesis
prostate gland morphogenesis
cochlea morphogenesis
regulation of T cell differentiation in thymus
spinal cord patterning
central nervous system projection neuron axonogenesis