GLO1

Entrez Summary: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis. {ECO:0000269|PubMed:19199007, ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Glyoxalase
Glyoxalase 2

lactoylglutathione lyase activity
methylglyoxal metabolic process
osteoclast differentiation
cellular aldehyde metabolic process
glutathione metabolic process
pyruvate metabolic process
cellular ketone metabolic process
myeloid leukocyte differentiation
cellular modified amino acid metabolic process
myeloid cell differentiation
leukocyte differentiation
sulfur compound metabolic process
cofactor metabolic process
carbohydrate metabolic process
peptide metabolic process
monocarboxylic acid metabolic process
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
cellular amide metabolic process
zinc ion binding
negative regulation of apoptotic process
negative regulation of programmed cell death
carboxylic acid metabolic process
negative regulation of cell death
oxoacid metabolic process
organic acid metabolic process
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
small molecule metabolic process