GLP1R

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). {ECO:0000250|UniProtKB:O35659, ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tunicamycin 0.04μM R07 exp418	-1.88
Phenformin 20μM R03 exp143	-1.87
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.72

7tm 2
HRM

glucagon-like peptide 1 receptor activity
glucagon receptor activity
response to psychosocial stress
cellular response to glucagon stimulus
response to glucagon
positive regulation of blood pressure
activation of adenylate cyclase activity
G protein-coupled peptide receptor activity
peptide hormone binding
adenylate cyclase-activating G protein-coupled receptor signaling pathway
transmembrane signaling receptor activity
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
regulation of insulin secretion
regulation of blood pressure
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of peptide hormone secretion
regulation of heart contraction
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
learning or memory
cellular response to peptide hormone stimulus
regulation of hormone secretion
positive regulation of cytosolic calcium ion concentration
regulation of blood circulation
cognition
cellular response to peptide
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
blood circulation
response to peptide hormone
circulatory system process
cellular calcium ion homeostasis
calcium ion homeostasis
regulation of protein secretion
cellular divalent inorganic cation homeostasis
response to peptide
divalent inorganic cation homeostasis
regulation of peptide secretion
regulation of hormone levels
cellular metal ion homeostasis