GLS2

Entrez Summary: N/A
UniProt Summary: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	-1.89
Nocodazole 0.2μM R02 exp64	1.7

glutaminase activity
glutamine catabolic process
glutamate biosynthetic process
dicarboxylic acid biosynthetic process
glutamine family amino acid biosynthetic process
glutamine metabolic process
glutamine family amino acid catabolic process
glutamate secretion
glutamate metabolic process
acidic amino acid transport
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
dicarboxylic acid transport
acid secretion
cellular amino acid biosynthetic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
reactive oxygen species metabolic process
amino acid transport
cellular amino acid catabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid transport
organic acid transport
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial matrix
small molecule catabolic process
organic anion transport
anion transport
small molecule biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
secretion by cell
organic acid metabolic process
export from cell
organonitrogen compound catabolic process
secretion