GLS [The Human Chemical-Genetic Interaction Map Project]

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======= GLS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GLS
  * **<color #00a2e8>Official Name</color>**: glutaminase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2744|2744]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94925|O94925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GLS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GLS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glutaminase|
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamine catabolic process|
|glutaminase activity|
|glutamate biosynthetic process|
|suckling behavior|
|regulation of respiratory gaseous exchange by nervous system process|
|dicarboxylic acid biosynthetic process|
|regulation of respiratory system process|
|glutamine family amino acid biosynthetic process|
|regulation of respiratory gaseous exchange|
|glutamine metabolic process|
|glutamine family amino acid catabolic process|
|glutamate secretion|
|glutamate metabolic process|
|acidic amino acid transport|
|alpha-amino acid biosynthetic process|
|multi-organism behavior|
|glutamine family amino acid metabolic process|
|dicarboxylic acid transport|
|acid secretion|
|cellular amino acid biosynthetic process|
|feeding behavior|
|protein homotetramerization|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|amino acid transport|
|cellular amino acid catabolic process|
|protein tetramerization|
|alpha-amino acid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|organic acid transport|
|carboxylic acid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|protein homooligomerization|
|mitochondrial matrix|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|small molecule catabolic process|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|protein complex oligomerization|
|behavior|
|anion transport|
|small molecule biosynthetic process|
|regulation of system process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|secretion|
|mitochondrion|
|ion transport|
|nervous system process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.15|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.76|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.82|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.29|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.5|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1592
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GLS Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>