GLS

Entrez Summary: N/A
UniProt Summary: Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-2.15
Dimethyloxaloylglycine 100μM R05 exp229	-1.76
Adefovir 20μM R07 exp332	1.82
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.29
CB-839 10μM R05 exp224	2.5
Aminopterin 0.005μM R07 exp335	2.81

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutamine catabolic process
glutaminase activity
glutamate biosynthetic process
suckling behavior
regulation of respiratory gaseous exchange by nervous system process
dicarboxylic acid biosynthetic process
regulation of respiratory system process
glutamine family amino acid biosynthetic process
regulation of respiratory gaseous exchange
glutamine metabolic process
glutamine family amino acid catabolic process
glutamate secretion
glutamate metabolic process
acidic amino acid transport
alpha-amino acid biosynthetic process
multi-organism behavior
glutamine family amino acid metabolic process
dicarboxylic acid transport
acid secretion
cellular amino acid biosynthetic process
feeding behavior
protein homotetramerization
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
amino acid transport
cellular amino acid catabolic process
protein tetramerization
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
organic acid transport
carboxylic acid transport
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
protein homooligomerization
mitochondrial matrix
chemical synaptic transmission
anterograde trans-synaptic signaling
small molecule catabolic process