GMPPB [The Human Chemical-Genetic Interaction Map Project]

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======= GMPPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GMPPB
  * **<color #00a2e8>Official Name</color>**: GDP-mannose pyrophosphorylase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29925|29925]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5P6|Q9Y5P6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GMPPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GMPPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615320|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. {ECO:0000250|UniProtKB:P0C5I2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTP transferase|
|NTP transf 3|
|Hexapep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannose-1-phosphate guanylyltransferase activity|
|GDP-mannose biosynthetic process|
|GDP-mannose metabolic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|GTP binding|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-3.01|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.88|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.64|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.63|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.61|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.6|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.58|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.54|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.49|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.48|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.44|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-2.43|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.41|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.38|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.35|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.33|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.29|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.28|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.28|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.25|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.23|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.18|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.17|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.16|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.14|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.14|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.13|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.13|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.08|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.07|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.07|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.06|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.06|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.06|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.03|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.01|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.01|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.98|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.97|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.95|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.95|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.94|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.94|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.94|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.92|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.92|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.91|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.91|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.9|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.89|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.89|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.88|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.87|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.86|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.86|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.86|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.86|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.84|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.84|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.83|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.82|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.81|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.8|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.8|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.78|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.73|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.72|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.7|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.7|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.7|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.71|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.9|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.91|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.97|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.97|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.97|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.98|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.04|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.1|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.21|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.34|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.35|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.38|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.39|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.67|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.86|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.88|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.17|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|3.35|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.49|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|3.59|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.62|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.67|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.67|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.7|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.76|
|[[:results:exp539|42°C R08 exp539]]|4.36|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|4.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.746|
|[[:human genes:t:thg1l|THG1L]]|0.725|
|[[:human genes:r:rnmt|RNMT]]|0.703|
|[[:human genes:g:gfpt1|GFPT1]]|0.703|
|[[:human genes:r:rptor|RPTOR]]|0.699|
|[[:human genes:d:dpagt1|DPAGT1]]|0.691|
|[[:human genes:u:uap1|UAP1]]|0.671|
|[[:human genes:a:alg1|ALG1]]|0.667|
|[[:human genes:a:adsl|ADSL]]|0.658|
|[[:human genes:h:hspd1|HSPD1]]|0.658|
|[[:human genes:t:triap1|TRIAP1]]|0.651|
|[[:human genes:r:rtcb|RTCB]]|0.645|
|[[:human genes:a:alg2|ALG2]]|0.636|
|[[:human genes:r:rpp21|RPP21]]|0.636|
|[[:human genes:a:alg13|ALG13]]|0.635|
|[[:human genes:n:nars|NARS]]|0.632|
|[[:human genes:a:atxn10|ATXN10]]|0.627|
|[[:human genes:h:hars|HARS]]|0.624|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.622|
|[[:human genes:m:mtor|MTOR]]|0.612|
|[[:human genes:e:eprs|EPRS]]|0.609|
|[[:human genes:c:ccdc101|CCDC101]]|0.608|
|[[:human genes:s:srp14|SRP14]]|0.607|
|[[:human genes:a:atp5j|ATP5J]]|0.606|
|[[:human genes:p:pelo|PELO]]|0.604|
|[[:human genes:u:utp23|UTP23]]|0.604|
|[[:human genes:e:eny2|ENY2]]|0.603|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.597|
|[[:human genes:m:med16|MED16]]|0.597|
|[[:human genes:g:gnb1l|GNB1L]]|0.596|
|[[:human genes:c:csnk2b|CSNK2B]]|0.593|
|[[:human genes:d:dohh|DOHH]]|0.592|
|[[:human genes:y:yars|YARS]]|0.592|
|[[:human genes:t:telo2|TELO2]]|0.59|
|[[:human genes:a:aars|AARS]]|0.59|
|[[:human genes:n:nae1|NAE1]]|0.589|
|[[:human genes:d:ddost|DDOST]]|0.584|
|[[:human genes:t:tsen54|TSEN54]]|0.583|
|[[:human genes:r:rpn1|RPN1]]|0.582|
|[[:human genes:o:osgep|OSGEP]]|0.581|
|[[:human genes:m:mars|MARS]]|0.58|
|[[:human genes:t:tti2|TTI2]]|0.579|
|[[:human genes:b:bap1|BAP1]]|0.578|
|[[:human genes:h:hccs|HCCS]]|0.573|
|[[:human genes:v:vezt|VEZT]]|0.572|
|[[:human genes:o:oraov1|ORAOV1]]|0.568|
|[[:human genes:e:exoc4|EXOC4]]|0.568|
|[[:human genes:d:dad1|DAD1]]|0.565|
|[[:human genes:e:eif4e|EIF4E]]|0.563|
|[[:human genes:d:dhps|DHPS]]|0.563|
|[[:human genes:a:alg5|ALG5]]|0.561|
|[[:human genes:c:cct7|CCT7]]|0.56|
|[[:human genes:u:uhrf1|UHRF1]]|0.558|
|[[:human genes:t:tti1|TTI1]]|0.557|
|[[:human genes:c:chchd4|CHCHD4]]|0.55|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.55|
|[[:human genes:e:eif3f|EIF3F]]|0.548|
|[[:human genes:m:med4|MED4]]|0.547|
|[[:human genes:t:trnt1|TRNT1]]|0.546|
|[[:human genes:t:tbca|TBCA]]|0.544|
|[[:human genes:p:pam16|PAM16]]|0.541|
|[[:human genes:r:rpe|RPE]]|0.537|
|[[:human genes:l:lsm11|LSM11]]|0.536|
|[[:human genes:d:dpf2|DPF2]]|0.535|
|[[:human genes:u:uxt|UXT]]|0.535|
|[[:human genes:g:gemin8|GEMIN8]]|0.532|
|[[:human genes:e:elac2|ELAC2]]|0.531|
|[[:human genes:t:tamm41|TAMM41]]|0.531|
|[[:human genes:p:plaa|PLAA]]|0.53|
|[[:human genes:t:tsen34|TSEN34]]|0.529|
|[[:human genes:m:meaf6|MEAF6]]|0.529|
|[[:human genes:o:oip5|OIP5]]|0.528|
|[[:human genes:c:cbfb|CBFB]]|0.526|
|[[:human genes:d:ddx20|DDX20]]|0.526|
|[[:human genes:c:casp9|CASP9]]|0.526|
|[[:human genes:g:gemin5|GEMIN5]]|0.525|
|[[:human genes:w:wdr24|WDR24]]|0.525|
|[[:human genes:s:srp68|SRP68]]|0.524|
|[[:human genes:t:thoc3|THOC3]]|0.522|
|[[:human genes:u:uba3|UBA3]]|0.521|
|[[:human genes:t:trmt5|TRMT5]]|0.521|
|[[:human genes:b:bak1|BAK1]]|0.518|
|[[:human genes:v:vrk1|VRK1]]|0.517|
|[[:human genes:p:ppa2|PPA2]]|0.517|
|[[:human genes:a:apaf1|APAF1]]|0.516|
|[[:human genes:a:alg14|ALG14]]|0.513|
|[[:human genes:e:exoc3|EXOC3]]|0.512|
|[[:human genes:s:sec61g|SEC61G]]|0.512|
|[[:human genes:h:haus8|HAUS8]]|0.512|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.511|
|[[:human genes:c:cars|CARS]]|0.511|
|[[:human genes:s:ssb|SSB]]|0.511|
|[[:human genes:m:mapk14|MAPK14]]|0.51|
|[[:human genes:d:dr1|DR1]]|0.509|
|[[:human genes:m:mllt1|MLLT1]]|0.507|
|[[:human genes:t:tgs1|TGS1]]|0.507|
|[[:human genes:s:seh1l|SEH1L]]|0.504|
|[[:human genes:c:cycs|CYCS]]|0.501|
|[[:human genes:n:nsmce1|NSMCE1]]|0.501|
|[[:human genes:s:slc25a26|SLC25A26]]|0.499|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.499|
|[[:human genes:u:ube2g2|UBE2G2]]|0.497|
|[[:human genes:s:slc35b1|SLC35B1]]|0.496|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.495|
|[[:human genes:w:wdr59|WDR59]]|0.495|
|[[:human genes:d:dolk|DOLK]]|0.493|
|[[:human genes:s:spcs2|SPCS2]]|0.492|
|[[:human genes:a:atp5b|ATP5B]]|0.491|
|[[:human genes:c:crcp|CRCP]]|0.491|
|[[:human genes:l:lsm10|LSM10]]|0.491|
|[[:human genes:t:tmem41b|TMEM41B]]|0.49|
|[[:human genes:p:ppp4c|PPP4C]]|0.49|
|[[:human genes:s:slc25a19|SLC25A19]]|0.489|
|[[:human genes:z:znf608|ZNF608]]|0.488|
|[[:human genes:r:rabggtb|RABGGTB]]|0.488|
|[[:human genes:o:otud5|OTUD5]]|0.487|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.487|
|[[:human genes:r:rad1|RAD1]]|0.485|
|[[:human genes:t:ten1|TEN1]]|0.485|
|[[:human genes:a:atp5o|ATP5O]]|0.485|
|[[:human genes:g:gpn2|GPN2]]|0.485|
|[[:human genes:s:srp72|SRP72]]|0.485|
|[[:human genes:z:znf259|ZNF259]]|0.483|
|[[:human genes:t:taz|TAZ]]|0.483|
|[[:human genes:p:polr3h|POLR3H]]|0.483|
|[[:human genes:v:vhl|VHL]]|0.482|
|[[:human genes:p:ppcs|PPCS]]|0.482|
|[[:human genes:f:faf2|FAF2]]|0.48|
|[[:human genes:z:zrsr2|ZRSR2]]|0.479|
|[[:human genes:c:cep57|CEP57]]|0.479|
|[[:human genes:e:eno1|ENO1]]|0.479|
|[[:human genes:g:gfer|GFER]]|0.479|
|[[:human genes:t:ttc4|TTC4]]|0.478|
|[[:human genes:p:pax5|PAX5]]|0.477|
|[[:human genes:g:gemin7|GEMIN7]]|0.476|
|[[:human genes:r:rpia|RPIA]]|0.475|
|[[:human genes:u:ubqln1|UBQLN1]]|0.474|
|[[:human genes:d:ddx55|DDX55]]|0.473|
|[[:human genes:u:urm1|URM1]]|0.47|
|[[:human genes:p:polr3b|POLR3B]]|0.469|
|[[:human genes:d:derl2|DERL2]]|0.468|
|[[:human genes:p:psmg4|PSMG4]]|0.467|
|[[:human genes:a:alg6|ALG6]]|0.466|
|[[:human genes:t:tle4|TLE4]]|0.466|
|[[:human genes:t:tprkb|TPRKB]]|0.463|
|[[:human genes:t:timm13|TIMM13]]|0.463|
|[[:human genes:a:atic|ATIC]]|0.462|
|[[:human genes:t:tbp|TBP]]|0.462|
|[[:human genes:t:txnl4b|TXNL4B]]|0.462|
|[[:human genes:a:abcb7|ABCB7]]|0.461|
|[[:human genes:g:gtf3a|GTF3A]]|0.461|
|[[:human genes:s:snf8|SNF8]]|0.458|
|[[:human genes:n:nsd1|NSD1]]|0.457|
|[[:human genes:p:pdap1|PDAP1]]|0.457|
|[[:human genes:d:dhdds|DHDDS]]|0.457|
|[[:human genes:q:qars|QARS]]|0.455|
|[[:human genes:s:sdha|SDHA]]|0.454|
|[[:human genes:w:wdr92|WDR92]]|0.454|
|[[:human genes:a:atp2a2|ATP2A2]]|0.453|
|[[:human genes:t:timm22|TIMM22]]|0.453|
|[[:human genes:d:dnajc3|DNAJC3]]|0.451|
|[[:human genes:e:eftud1|EFTUD1]]|0.451|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.45|
|[[:human genes:p:ppp6c|PPP6C]]|0.45|
|[[:human genes:v:vmp1|VMP1]]|0.45|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.449|
|[[:human genes:w:wars|WARS]]|0.447|
|[[:human genes:l:lsmd1|LSMD1]]|0.447|
|[[:human genes:s:spcs3|SPCS3]]|0.447|
|[[:human genes:c:crls1|CRLS1]]|0.445|
|[[:human genes:s:sec62|SEC62]]|0.445|
|[[:human genes:k:kdsr|KDSR]]|0.445|
|[[:human genes:t:tbcb|TBCB]]|0.444|
|[[:human genes:p:pik3r4|PIK3R4]]|0.442|
|[[:human genes:t:thoc6|THOC6]]|0.442|
|[[:human genes:t:tsen2|TSEN2]]|0.44|
|[[:human genes:g:gemin6|GEMIN6]]|0.44|
|[[:human genes:m:med23|MED23]]|0.439|
|[[:human genes:f:fen1|FEN1]]|0.438|
|[[:human genes:c:cep350|CEP350]]|0.438|
|[[:human genes:c:c15orf41|C15orf41]]|0.437|
|[[:human genes:t:tbcd|TBCD]]|0.437|
|[[:human genes:d:dicer1|DICER1]]|0.434|
|[[:human genes:z:zzz3|ZZZ3]]|0.433|
|[[:human genes:c:ctc1|CTC1]]|0.433|
|[[:human genes:z:zbtb11|ZBTB11]]|0.433|
|[[:human genes:f:fh|FH]]|0.432|
|[[:human genes:d:dctn6|DCTN6]]|0.432|
|[[:human genes:s:snapc5|SNAPC5]]|0.429|
|[[:human genes:d:dkc1|DKC1]]|0.429|
|[[:human genes:r:rft1|RFT1]]|0.428|
|[[:human genes:p:pisd|PISD]]|0.428|
|[[:human genes:i:iars2|IARS2]]|0.428|
|[[:human genes:c:c21orf59|C21orf59]]|0.426|
|[[:human genes:n:naf1|NAF1]]|0.426|
|[[:human genes:n:nxt1|NXT1]]|0.426|
|[[:human genes:n:nupl2|NUPL2]]|0.424|
|[[:human genes:m:mbtps2|MBTPS2]]|0.424|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.424|
|[[:human genes:u:ube2k|UBE2K]]|0.424|
|[[:human genes:e:ercc2|ERCC2]]|0.423|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.423|
|[[:human genes:v:vdac2|VDAC2]]|0.423|
|[[:human genes:t:trmt10a|TRMT10A]]|0.423|
|[[:human genes:t:tmed10|TMED10]]|0.422|
|[[:human genes:z:zfx|ZFX]]|0.421|
|[[:human genes:p:pggt1b|PGGT1B]]|0.421|
|[[:human genes:u:ube2j1|UBE2J1]]|0.419|
|[[:human genes:n:naa20|NAA20]]|0.419|
|[[:human genes:f:fnta|FNTA]]|0.418|
|[[:human genes:c:cdipt|CDIPT]]|0.418|
|[[:human genes:t:trim28|TRIM28]]|0.418|
|[[:human genes:d:dhx29|DHX29]]|0.418|
|[[:human genes:w:wdr82|WDR82]]|0.418|
|[[:human genes:p:phb|PHB]]|0.418|
|[[:human genes:x:xrcc3|XRCC3]]|0.417|
|[[:human genes:n:nbn|NBN]]|0.417|
|[[:human genes:d:ddx39a|DDX39A]]|0.417|
|[[:human genes:s:srprb|SRPRB]]|0.415|
|[[:human genes:a:atp5a1|ATP5A1]]|0.414|
|[[:human genes:a:actr10|ACTR10]]|0.414|
|[[:human genes:n:n6amt1|N6AMT1]]|0.413|
|[[:human genes:m:march5|MARCH5]]|0.412|
|[[:human genes:x:xrcc2|XRCC2]]|0.412|
|[[:human genes:e:elp3|ELP3]]|0.411|
|[[:human genes:d:dusp12|DUSP12]]|0.411|
|[[:human genes:r:romo1|ROMO1]]|0.411|
|[[:human genes:m:mrps33|MRPS33]]|0.41|
|[[:human genes:b:bcs1l|BCS1L]]|0.41|
|[[:human genes:c:chordc1|CHORDC1]]|0.41|
|[[:human genes:r:rad50|RAD50]]|0.41|
|[[:human genes:i:id3|ID3]]|0.409|
|[[:human genes:r:rbmx2|RBMX2]]|0.408|
|[[:human genes:o:obfc1|OBFC1]]|0.407|
|[[:human genes:r:rfk|RFK]]|0.406|
|[[:human genes:s:srpk1|SRPK1]]|0.406|
|[[:human genes:e:eef1e1|EEF1E1]]|0.406|
|[[:human genes:f:fli1|FLI1]]|0.406|
|[[:human genes:s:stt3a|STT3A]]|0.405|
|[[:human genes:a:atp5i|ATP5I]]|0.404|
|[[:human genes:k:kdm8|KDM8]]|0.404|
|[[:human genes:m:mis18a|MIS18A]]|0.403|
|[[:human genes:t:taf1a|TAF1A]]|0.403|
|[[:human genes:w:wdr1|WDR1]]|0.402|
|[[:human genes:c:c14orf166|C14orf166]]|0.401|
|[[:human genes:u:uba5|UBA5]]|0.401|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 235/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|4/28|
|bone|3/26|
|breast|8/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|15/21|
|liver|5/20|
|lung|22/75|
|lymphocyte|7/16|
|ovary|7/26|
|pancreas|8/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GMPPB Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>