GMPPB

Gene Information

Official Symbol: GMPPB
Official Name: GDP-mannose pyrophosphorylase B
Aliases and Previous Symbols: N/A
Entrez ID: 29925
UniProt: Q9Y5P6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009].
UniProt Summary: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. {ECO:0000250|UniProtKB:P0C5I2}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nifuroxazide 1μM R01 exp51	-3.01
Tubacin 1.6μM R07 exp416	-2.88
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.64
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.63
VER-155008 3.9μM R06 exp301	-2.61
Vemurafenib 6.6μM R08 exp434	-2.6
EPZ-5676 30μM R05 exp233	-2.58
BI-6727 0.001μM R01 exp42	-2.54
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.49
A-395 10μM R05 exp218	-2.48
NFN1 0.1μM R01 exp49	-2.44
UM131593 0.1μM R01 exp58	-2.43
Selumetinib 20μM R02 exp81	-2.41
Radicicol 0.16μM R05 exp242	-2.38
NMS-873 0.07μM R07 exp380	-2.35
FTY720 3μM R08 exp483	-2.33
Chlorpromazine 10μM R07 exp344	-2.29
BS-181 20μM R08 exp461	-2.28
Cannabidiol 13μM R08 exp465	-2.28
Dimethyloxaloylglycine 100μM R05 exp229	-2.25
RS-1 10μM R08 exp519	-2.23
LJH685 5μM R02 exp73	-2.18
Chloroquine 32μM R08 exp470	-2.17
PFI-2 4μM R05 exp239	-2.16
CCT251545 0.2μM R06 exp271	-2.14
CVT-10216 0.1μM R06 exp278	-2.14
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.13
Docetaxel 0.002μM R01 exp45	-2.13
Ibrutinib 10μM R08 exp442	-2.08
Dimethyloxaloylglycine 11μM R07 exp314	-2.07
Vinorelbine 0.001μM R05 exp249	-2.07
2-Methoxyestradiol 0.2μM R01 exp40	-2.06
Mdivi-1 15μM R05 exp217	-2.06
Taxol 0.002μM R01 exp54	-2.06
BI-2536 0.001μM R01 exp41	-2.03
Cisplatin 0.35μM R06 exp273	-2.01
Lapatinib 5μM R01 exp47	-2.01
Trichostatin-A 0.06μM R07 exp415	-1.98
Rifampicin 1μM R00 exp31	-1.97
Etoposide 0.1μM R05 exp198	-1.95
Pifithrin-alpha 20μM R07 exp390	-1.95
5-Azacytidine 2μM R07 exp330	-1.94
CCCP 0.1μM R00 exp10	-1.94
Geldanamycin 0.01μM R05 exp235	-1.94
ABT-702 5μM R07 exp318	-1.92
LLY-284 2.6μM R06 exp291	-1.92
Rapamycin 2μM R07 exp306	-1.91
SGC0946 7μM R03 exp151	-1.91
Ribavirin 10μM R01 exp52	-1.9
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.89
GSK461364A 0.005μM R03 exp125	-1.89
Methotrexate 0.01μM R08 exp501	-1.88
Thalidomide 20μM R07 exp406	-1.87
GSK-J4 1μM R07 exp362	-1.86
proTAME 5μM R04 exp187	-1.86
Trientine 500μM R08 exp534	-1.86
FBS-Wisent 0.1 R07 exp426	-1.86
Dynasore 7μM R08 exp436	-1.84
Nicotinamide 2000μM R01 exp50	-1.84
Cabazitaxel 0.001μM R05 exp223	-1.83
2-Methoxyestradiol 0.55μM R07 exp310	-1.82
Zebularine 20μM R07 exp423	-1.81
A-196 10μM R03 exp114	-1.8
GSK2606414 1μM R05 exp236	-1.8
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.78
LB-100 2μM R05 exp210	-1.78
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.74
Bortezomib 0.005μM R00 exp6	-1.73
Vinblastine 0.002μM R01 exp60	-1.72
Disulfiram 4.3μM R06 exp281	-1.7
HMS-I2 1μM R06 exp286	-1.7
Menadione 5μM R06 exp292	-1.7
Tubastatin-A 2.5μM R07 exp417	-1.7
Ammonium tetrathiomolybdate 10μM R08 exp448	1.71
Monensin 0.3μM R08 exp507	1.71
ONC212 0.15μM R08 exp513	1.8
HMS-I1 10μM R06 exp256	1.9
BI-2536 0.02μM R03 exp96	1.91
DABN 20μM R00 exp17	1.97
Etoposide 0.3μM R05 exp199	1.97
Rotenone 20μM R00 exp34	1.97
Etoposide 1μM R00 exp19	1.98
CI-1040 9.5μM R08 exp472	2
Pimelic-diphenylamide-106 5μM R00 exp28	2.04
Aphidicolin 0.4μM R08 exp440	2.1
6-Thio-2-deoxyguanosine 2μM R06 exp259	2.21
Vitamin-D3 40μM R08 exp536	2.34
Brefeldin A 0.02μM R00 exp8	2.35
Doxorubicin 0.02μM R08 exp478	2.38
PU-H71 1μM R08 exp515	2.39
Atovaquone 15μM R08 exp451	2.67
RO-3307 4.7μM R02 exp80	2.86
Nocodazole 0.2μM R02 exp64	2.88
GSK461364A 0.1μM R03 exp126	2.94
Tanespimycin 14μM R08 exp527	3.17
Salinomycin 3.5μM R08 exp521	3.35
Actinomycin-D 0.001μM R00 exp3	3.49
CFI-400945 25μM R08 exp469	3.59
SNS-032 15μM R08 exp443	3.62
Bleomycin 5μM R08 exp459	3.67
MLN-4924 2μM R00 exp22	3.67
Benzoate 20000μM R08 exp456	3.7
5-Fluorouracil 20μM R00 exp2	3.76
42°C R08 exp539	4.36
THZ1 0.06μM R08 exp531	4.74

Gene	Correlation
PMM2	0.746
THG1L	0.725
RNMT	0.703
GFPT1	0.703
RPTOR	0.699
DPAGT1	0.691
UAP1	0.671
ALG1	0.667
ADSL	0.658
HSPD1	0.658
TRIAP1	0.651
RTCB	0.645
ALG2	0.636
RPP21	0.636
ALG13	0.635
NARS	0.632
ATXN10	0.627
HARS	0.624
GTF3C3	0.622
MTOR	0.612
EPRS	0.609
CCDC101	0.608
SRP14	0.607
ATP5J	0.606
PELO	0.604
UTP23	0.604
ENY2	0.603
GTF3C2	0.597
MED16	0.597
GNB1L	0.596
CSNK2B	0.593
DOHH	0.592
YARS	0.592
TELO2	0.59
AARS	0.59
NAE1	0.589
DDOST	0.584
TSEN54	0.583
RPN1	0.582
OSGEP	0.581
MARS	0.58
TTI2	0.579
BAP1	0.578
HCCS	0.573
VEZT	0.572
ORAOV1	0.568
EXOC4	0.568
DAD1	0.565
EIF4E	0.563
DHPS	0.563
ALG5	0.561
CCT7	0.56
UHRF1	0.558
TTI1	0.557
CHCHD4	0.55
GTF3C4	0.55
EIF3F	0.548
MED4	0.547
TRNT1	0.546
TBCA	0.544
PAM16	0.541
RPE	0.537
LSM11	0.536
DPF2	0.535
UXT	0.535
GEMIN8	0.532
ELAC2	0.531
TAMM41	0.531
PLAA	0.53
TSEN34	0.529
MEAF6	0.529
OIP5	0.528
CBFB	0.526
DDX20	0.526
CASP9	0.526
GEMIN5	0.525
WDR24	0.525
SRP68	0.524
THOC3	0.522
UBA3	0.521
TRMT5	0.521
BAK1	0.518
VRK1	0.517
PPA2	0.517
APAF1	0.516
ALG14	0.513
EXOC3	0.512
SEC61G	0.512
HAUS8	0.512
PPP2R3C	0.511
CARS	0.511
SSB	0.511
MAPK14	0.51
DR1	0.509
MLLT1	0.507
TGS1	0.507
SEH1L	0.504
CYCS	0.501
NSMCE1	0.501
SLC25A26	0.499
GTF3C6	0.499
UBE2G2	0.497
SLC35B1	0.496
LAMTOR5	0.495
WDR59	0.495
DOLK	0.493
SPCS2	0.492
ATP5B	0.491
CRCP	0.491
LSM10	0.491
TMEM41B	0.49
PPP4C	0.49
SLC25A19	0.489
ZNF608	0.488
RABGGTB	0.488
OTUD5	0.487
GTF2A2	0.487
RAD1	0.485
TEN1	0.485
ATP5O	0.485
GPN2	0.485
SRP72	0.485
ZNF259	0.483
TAZ	0.483
POLR3H	0.483
VHL	0.482
PPCS	0.482
FAF2	0.48
ZRSR2	0.479
CEP57	0.479
ENO1	0.479
GFER	0.479
TTC4	0.478
PAX5	0.477
GEMIN7	0.476
RPIA	0.475
UBQLN1	0.474
DDX55	0.473
URM1	0.47
POLR3B	0.469
DERL2	0.468
PSMG4	0.467
ALG6	0.466
TLE4	0.466
TPRKB	0.463
TIMM13	0.463
ATIC	0.462
TBP	0.462
TXNL4B	0.462
ABCB7	0.461
GTF3A	0.461
SNF8	0.458
NSD1	0.457
PDAP1	0.457
DHDDS	0.457
QARS	0.455
SDHA	0.454
WDR92	0.454
ATP2A2	0.453
TIMM22	0.453
DNAJC3	0.451
EFTUD1	0.451
SUPV3L1	0.45
PPP6C	0.45
VMP1	0.45
CTDNEP1	0.449
WARS	0.447
LSMD1	0.447
SPCS3	0.447
CRLS1	0.445
SEC62	0.445
KDSR	0.445
TBCB	0.444
PIK3R4	0.442
THOC6	0.442
TSEN2	0.44
GEMIN6	0.44
MED23	0.439
FEN1	0.438
CEP350	0.438
C15orf41	0.437
TBCD	0.437
DICER1	0.434
ZZZ3	0.433
CTC1	0.433
ZBTB11	0.433
FH	0.432
DCTN6	0.432
SNAPC5	0.429
DKC1	0.429
RFT1	0.428
PISD	0.428
IARS2	0.428
C21orf59	0.426
NAF1	0.426
NXT1	0.426
NUPL2	0.424
MBTPS2	0.424
LAMTOR4	0.424
UBE2K	0.424
ERCC2	0.423
AASDHPPT	0.423
VDAC2	0.423
TRMT10A	0.423
TMED10	0.422
ZFX	0.421
PGGT1B	0.421
UBE2J1	0.419
NAA20	0.419
FNTA	0.418
CDIPT	0.418
TRIM28	0.418
DHX29	0.418
WDR82	0.418
PHB	0.418
XRCC3	0.417
NBN	0.417
DDX39A	0.417
SRPRB	0.415
ATP5A1	0.414
ACTR10	0.414
N6AMT1	0.413
MARCH5	0.412
XRCC2	0.412
ELP3	0.411
DUSP12	0.411
ROMO1	0.411
MRPS33	0.41
BCS1L	0.41
CHORDC1	0.41
RAD50	0.41
ID3	0.409
RBMX2	0.408
OBFC1	0.407
RFK	0.406
SRPK1	0.406
EEF1E1	0.406
FLI1	0.406
STT3A	0.405
ATP5I	0.404
KDM8	0.404
MIS18A	0.403
TAF1A	0.403
WDR1	0.402
C14orf166	0.401
UBA5	0.401
GTF3C5	0.401

Global Fraction of Cell Lines Where Essential: 235/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	4/28
bone	3/26
breast	8/33
central nervous system	6/56
cervix	1/4
colorectal	10/17
esophagus	4/13
fibroblast	0/1
gastric	11/16
kidney	15/21
liver	5/20
lung	22/75
lymphocyte	7/16
ovary	7/26
pancreas	8/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	0/1
skin	14/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	11/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 176
Expression level (log2 read counts): 5.89

Expression Distribution

NTP transferase
NTP transf 3
Hexapep

mannose-1-phosphate guanylyltransferase activity
GDP-mannose biosynthetic process
GDP-mannose metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
GTP binding
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process