GNAT2 [The Human Chemical-Genetic Interaction Map Project]

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======= GNAT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNAT2
  * **<color #00a2e8>Official Name</color>**: G protein subunit alpha transducin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2780|2780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19087|P19087]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNAT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNAT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Arf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal cone cell differentiation|
|retinal cone cell development|
|response to light intensity|
|G protein-coupled photoreceptor activity|
|photoreceptor outer segment membrane|
|detection of light stimulus involved in visual perception|
|detection of light stimulus involved in sensory perception|
|camera-type eye photoreceptor cell differentiation|
|G-protein beta/gamma-subunit complex binding|
|heterotrimeric G-protein complex|
|eye photoreceptor cell development|
|Wnt signaling pathway, calcium modulating pathway|
|detection of chemical stimulus involved in sensory perception of bitter taste|
|phototransduction|
|sensory perception of bitter taste|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|detection of chemical stimulus involved in sensory perception of taste|
|detection of visible light|
|retina morphogenesis in camera-type eye|
|photoreceptor inner segment|
|neural retina development|
|photoreceptor cell differentiation|
|photoreceptor outer segment|
|detection of light stimulus|
|G protein-coupled receptor binding|
|sensory perception of taste|
|camera-type eye morphogenesis|
|detection of external stimulus|
|detection of abiotic stimulus|
|non-canonical Wnt signaling pathway|
|retina development in camera-type eye|
|eye morphogenesis|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|visual perception|
|sensory perception of light stimulus|
|protein folding|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|sensory organ morphogenesis|
|positive regulation of cytosolic calcium ion concentration|
|response to light stimulus|
|camera-type eye development|
|regulation of cytosolic calcium ion concentration|
|GTPase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|visual system development|
|sensory system development|
|GTP binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|response to radiation|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|detection of chemical stimulus involved in sensory perception|
|divalent inorganic cation homeostasis|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cellular homeostasis|
|animal organ morphogenesis|
|sensory perception|
|neuron differentiation|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNAT2 Expression in NALM6 Cells: -1.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>