GNAT2

Gene Information

Official Symbol: GNAT2
Official Name: G protein subunit alpha transducin 2
Aliases and Previous Symbols: N/A
Entrez ID: 2780
UniProt: P19087
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008].
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6727
Expression level (log2 read counts): -1.13

Expression Distribution

G-alpha
Arf

retinal cone cell differentiation
retinal cone cell development
response to light intensity
G protein-coupled photoreceptor activity
photoreceptor outer segment membrane
detection of light stimulus involved in visual perception
detection of light stimulus involved in sensory perception
camera-type eye photoreceptor cell differentiation
G-protein beta/gamma-subunit complex binding
heterotrimeric G-protein complex
eye photoreceptor cell development
Wnt signaling pathway, calcium modulating pathway
detection of chemical stimulus involved in sensory perception of bitter taste
phototransduction
sensory perception of bitter taste
eye photoreceptor cell differentiation
photoreceptor cell development
detection of chemical stimulus involved in sensory perception of taste
detection of visible light
retina morphogenesis in camera-type eye
photoreceptor inner segment
neural retina development
photoreceptor cell differentiation
photoreceptor outer segment
detection of light stimulus
G protein-coupled receptor binding
sensory perception of taste
camera-type eye morphogenesis
detection of external stimulus
detection of abiotic stimulus
non-canonical Wnt signaling pathway
retina development in camera-type eye
eye morphogenesis
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
visual perception
sensory perception of light stimulus
protein folding
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory organ morphogenesis
positive regulation of cytosolic calcium ion concentration