GNAZ

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arf
G-alpha

G protein-coupled serotonin receptor binding
G-protein beta/gamma-subunit complex binding
heterotrimeric G-protein complex
G protein-coupled receptor binding
cell body
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
nuclear envelope
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
protein folding
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GTPase activity
GTP binding
dendrite
endoplasmic reticulum
G protein-coupled receptor signaling pathway