GNL3L [The Human Chemical-Genetic Interaction Map Project]

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======= GNL3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GNL3L
  * **<color #00a2e8>Official Name</color>**: G protein nucleolar 3 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54552|54552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVN8|Q9NVN8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GNL3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GNL3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300873|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MMR HSR1|
|FeoB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein sumoylation|
|positive regulation of protein homodimerization activity|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of protein localization to chromosome, telomeric region|
|telomerase holoenzyme complex|
|negative regulation of telomere maintenance via telomerase|
|regulation of protein sumoylation|
|regulation of protein homodimerization activity|
|negative regulation of telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|negative regulation of protein ubiquitination|
|regulation of telomere maintenance|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of protein binding|
|negative regulation of protein binding|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|negative regulation of binding|
|positive regulation of binding|
|regulation of protein ubiquitination|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|regulation of protein stability|
|ribosome biogenesis|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|regulation of binding|
|GTP binding|
|ribonucleoprotein complex biogenesis|
|regulation of cellular protein localization|
|negative regulation of protein modification process|
|negative regulation of cellular component organization|
|nucleolus|
|regulation of cellular localization|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of molecular function|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.73|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.92|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.542|
|[[:human genes:p:polr2j3|POLR2J3]]|0.521|
|[[:human genes:n:nip7|NIP7]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 343/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|12/26|
|bone|13/26|
|breast|13/30|
|central nervous system|25/49|
|cervix|1/4|
|colorectal|7/17|
|esophagus|7/11|
|fibroblast|1/1|
|gastric|5/14|
|kidney|12/18|
|liver|6/19|
|lung|34/72|
|lymphocyte|5/16|
|ovary|13/25|
|pancreas|15/22|
|peripheral nervous system|8/15|
|plasma cell|6/12|
|prostate|0/1|
|skin|8/20|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|13/28|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GNL3L Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>