GNL3L

Gene Information

Official Symbol: GNL3L
Official Name: G protein nucleolar 3 like
Aliases and Previous Symbols: N/A
Entrez ID: 54552
UniProt: Q9NVN8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 343/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	12/28
blood	12/26
bone	13/26
breast	13/30
central nervous system	25/49
cervix	1/4
colorectal	7/17
esophagus	7/11
fibroblast	1/1
gastric	5/14
kidney	12/18
liver	6/19
lung	34/72
lymphocyte	5/16
ovary	13/25
pancreas	15/22
peripheral nervous system	8/15
plasma cell	6/12
prostate	0/1
skin	8/20
soft tissue	6/9
thyroid	1/2
upper aerodigestive	10/22
urinary tract	13/28
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 908
Expression level (log2 read counts): 6.04

Expression Distribution

Screen	Score
Rotenone 20μM R00 exp34	-1.73
CAY10603 0.55μM R08 exp467	1.71
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.92
THZ531 0.225μM R08 exp444	2.82

Gene	Correlation
GOLGA6L1	0.542
POLR2J3	0.521
NIP7	0.43

MMR HSR1
FeoB N

negative regulation of protein sumoylation
positive regulation of protein homodimerization activity
positive regulation of protein localization to chromosome, telomeric region
regulation of protein localization to chromosome, telomeric region
telomerase holoenzyme complex
negative regulation of telomere maintenance via telomerase
regulation of protein sumoylation
regulation of protein homodimerization activity
negative regulation of telomere maintenance via telomere lengthening
negative regulation of telomere maintenance
negative regulation of DNA biosynthetic process
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
negative regulation of protein ubiquitination
regulation of telomere maintenance
negative regulation of protein modification by small protein conjugation or removal
positive regulation of protein binding
negative regulation of protein binding
regulation of DNA biosynthetic process
negative regulation of DNA metabolic process
negative regulation of chromosome organization
negative regulation of binding
positive regulation of binding
regulation of protein ubiquitination
regulation of protein binding
regulation of protein modification by small protein conjugation or removal
regulation of protein stability
ribosome biogenesis
positive regulation of cellular protein localization
regulation of chromosome organization
regulation of DNA metabolic process
negative regulation of organelle organization
regulation of binding
GTP binding
ribonucleoprotein complex biogenesis
regulation of cellular protein localization
negative regulation of protein modification process
negative regulation of cellular component organization
nucleolus
regulation of cellular localization