GNMT

Entrez Summary: The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016].
UniProt Summary: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. {ECO:0000269|PubMed:15340920, ECO:0000269|PubMed:17660255}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycine N-methyltransferase activity
sarcosine metabolic process
S-adenosylhomocysteine metabolic process
S-adenosyl-L-methionine binding
folic acid binding
glycine binding
methionine metabolic process
S-adenosylmethionine metabolic process
one-carbon metabolic process
sulfur amino acid metabolic process
regulation of gluconeogenesis
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
aspartate family amino acid metabolic process
purine ribonucleoside metabolic process
energy reserve metabolic process
purine nucleoside metabolic process
ribonucleoside metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
protein homotetramerization
regulation of carbohydrate biosynthetic process
nucleoside metabolic process
regulation of glucose metabolic process
glycosyl compound metabolic process
regulation of cellular carbohydrate metabolic process
protein tetramerization
cellular carbohydrate metabolic process
cellular modified amino acid metabolic process
regulation of carbohydrate metabolic process
alpha-amino acid metabolic process
energy derivation by oxidation of organic compounds
coenzyme metabolic process
cellular amino acid metabolic process
methylation
protein homooligomerization
sulfur compound metabolic process
purine-containing compound metabolic process
generation of precursor metabolites and energy