GORASP1 [The Human Chemical-Genetic Interaction Map Project]

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======= GORASP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GORASP1
  * **<color #00a2e8>Official Name</color>**: golgi reassembly stacking protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64689|64689]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQQ3|Q9BQQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GORASP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GORASP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GRASP55 65|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ubiquitin protein ligase activity|
|negative regulation of dendrite morphogenesis|
|regulation of ubiquitin protein ligase activity|
|negative regulation of dendrite development|
|positive regulation of ubiquitin-protein transferase activity|
|regulation of ubiquitin-protein transferase activity|
|establishment of protein localization to plasma membrane|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|protein N-linked glycosylation|
|vesicle targeting|
|regulation of dendrite morphogenesis|
|vesicle budding from membrane|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of protein ubiquitination|
|Golgi organization|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|establishment of vesicle localization|
|negative regulation of cell projection organization|
|protein localization to plasma membrane|
|vesicle localization|
|regulation of protein ubiquitination|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|negative regulation of neuron differentiation|
|regulation of protein modification by small protein conjugation or removal|
|protein localization to cell periphery|
|macromolecule glycosylation|
|protein glycosylation|
|establishment of protein localization to membrane|
|glycosylation|
|negative regulation of neurogenesis|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|glycoprotein biosynthetic process|
|negative regulation of cell development|
|establishment of organelle localization|
|Golgi vesicle transport|
|glycoprotein metabolic process|
|endomembrane system organization|
|protein localization to membrane|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|organelle localization|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|membrane organization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of transferase activity|
|Golgi apparatus|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GORASP1 Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>