GORASP1

Gene Information

Official Symbol: GORASP1
Official Name: golgi reassembly stacking protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 64689
UniProt: Q9BQQ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6924
Expression level (log2 read counts): 4.77

Expression Distribution

positive regulation of ubiquitin protein ligase activity
negative regulation of dendrite morphogenesis
regulation of ubiquitin protein ligase activity
negative regulation of dendrite development
positive regulation of ubiquitin-protein transferase activity
regulation of ubiquitin-protein transferase activity
establishment of protein localization to plasma membrane
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment membrane
Golgi vesicle budding
protein N-linked glycosylation
vesicle targeting
regulation of dendrite morphogenesis
vesicle budding from membrane
negative regulation of cell morphogenesis involved in differentiation
positive regulation of protein ubiquitination
Golgi organization
positive regulation of protein modification by small protein conjugation or removal
regulation of dendrite development
negative regulation of neuron projection development
establishment of vesicle localization
negative regulation of cell projection organization
protein localization to plasma membrane
vesicle localization
regulation of protein ubiquitination
endoplasmic reticulum to Golgi vesicle-mediated transport
negative regulation of neuron differentiation
regulation of protein modification by small protein conjugation or removal
protein localization to cell periphery
macromolecule glycosylation
protein glycosylation
establishment of protein localization to membrane
glycosylation
negative regulation of neurogenesis
vesicle organization
regulation of cell morphogenesis involved in differentiation