GPAM [The Human Chemical-Genetic Interaction Map Project]

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======= GPAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPAM
  * **<color #00a2e8>Official Name</color>**: glycerol-3-phosphate acyltransferase, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57678|57678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCL2|Q9HCL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602395|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. {ECO:0000250|UniProtKB:P97564, ECO:0000269|PubMed:18238778}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity|
|glycerol-3-phosphate O-acyltransferase activity|
|glycerol-3-phosphate metabolic process|
|alditol phosphate metabolic process|
|CDP-diacylglycerol biosynthetic process|
|CDP-diacylglycerol metabolic process|
|triglyceride biosynthetic process|
|acylglycerol biosynthetic process|
|neutral lipid biosynthetic process|
|regulation of intracellular estrogen receptor signaling pathway|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|regulation of cholesterol metabolic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|regulation of alcohol biosynthetic process|
|triglyceride metabolic process|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of steroid biosynthetic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|mitochondrial membrane|
|pyrimidine-containing compound metabolic process|
|regulation of steroid metabolic process|
|mitochondrial outer membrane|
|regulation of lipid biosynthetic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|nucleotide biosynthetic process|
|phospholipid biosynthetic process|
|nucleoside phosphate biosynthetic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.92|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.94|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11073
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPAM Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>