GPAM

Gene Information

Official Symbol: GPAM
Official Name: glycerol-3-phosphate acyltransferase, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 57678
UniProt: Q9HCL2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. {ECO:0000250|UniProtKB:P97564, ECO:0000269|PubMed:18238778}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11073
Expression level (log2 read counts): 6.11

Expression Distribution

Screen	Score
Amiloride 100μM R08 exp447	-1.73
LY2090314 0.003μM R08 exp500 no dilution day6	1.92
Adefovir 20μM R07 exp332	1.94
DKK1 89ng/ml R08 exp477	1.98

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
glycerol-3-phosphate O-acyltransferase activity
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
triglyceride biosynthetic process
acylglycerol biosynthetic process
neutral lipid biosynthetic process
regulation of intracellular estrogen receptor signaling pathway
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
pyrimidine nucleotide biosynthetic process
regulation of cholesterol metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
regulation of alcohol biosynthetic process
triglyceride metabolic process
regulation of intracellular steroid hormone receptor signaling pathway
regulation of steroid biosynthetic process
acylglycerol metabolic process
neutral lipid metabolic process
mitochondrial membrane
pyrimidine-containing compound metabolic process
regulation of steroid metabolic process
mitochondrial outer membrane
regulation of lipid biosynthetic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process