GPAT2

Entrez Summary: N/A
UniProt Summary: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity. {ECO:0000250|UniProtKB:Q14DK4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity
glycerol-3-phosphate O-acyltransferase activity
piRNA biosynthetic process
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
piRNA metabolic process
triglyceride biosynthetic process
neutral lipid biosynthetic process
acylglycerol biosynthetic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
triglyceride metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
mitochondrial membrane
pyrimidine-containing compound metabolic process
mitochondrial outer membrane
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
ncRNA metabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process