GPATCH3

Gene Information

Official Symbol: GPATCH3
Official Name: G-patch domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 63906
UniProt: Q96I76
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768). {ECO:0000269|PubMed:28397860, ECO:0000269|PubMed:28414768}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5076
Expression level (log2 read counts): 4.09

Expression Distribution

negative regulation of RIG-I signaling pathway
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of RIG-I signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
negative regulation of defense response to virus
negative regulation of type I interferon production
regulation of defense response to virus
negative regulation of response to biotic stimulus
negative regulation of immune effector process
regulation of type I interferon production
nucleic acid binding
negative regulation of defense response
negative regulation of multi-organism process
negative regulation of cytokine production
negative regulation of response to external stimulus
negative regulation of immune system process
regulation of innate immune response
regulation of immune effector process
negative regulation of intracellular signal transduction
regulation of response to biotic stimulus
regulation of cytokine production
regulation of defense response
regulation of multi-organism process
regulation of response to external stimulus
regulation of immune response
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of response to stress
positive regulation of transcription, DNA-templated
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
positive regulation of RNA metabolic process
regulation of intracellular signal transduction
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process