GPATCH8 [The Human Chemical-Genetic Interaction Map Project]

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======= GPATCH8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPATCH8
  * **<color #00a2e8>Official Name</color>**: G-patch domain containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23131|23131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKJ3|Q9UKJ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPATCH8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPATCH8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614396|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C2H2 jaz|
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.21|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.94|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.84|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.73|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.73|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.77|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.87|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.9|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.9|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.96|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.08|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.21|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.43|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.47|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.61|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.83|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7925
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPATCH8 Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>