GPATCH8

Entrez Summary: The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aminopterin 0.005μM R07 exp335	-2.73
I-BRD9 4μM R07 exp365	-2.21
CoCl2 18μM R07 exp346	-1.94
Resminostat 0.5μM R07 exp393	-1.84
Thapsigargin 0.005μM R07 exp407	-1.73
Nocodazole 0.1μM R03 exp94	-1.72
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.73
Vinblastine 0.002μM R01 exp60	1.73
Mubritinib 0.2μM R01 exp48	1.77
BI-2536 0.0042μM R03 exp95	1.87
HMS-I2 10μM R06 exp288	1.9
Rucaparib 6.5μM R08 exp520	1.9
Nutlin-3A 1.6μM R06 exp294	1.96
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.97
AICAR 240μM R03 exp116	2.08
Apcin 25μM plus proTAME 2μM R04 exp177	2.21
AICAR 240μM R05 exp211	2.43
Taxol 0.004μM R03 exp103	2.47
ML-792 0.2μM R08 exp505	2.61
CR131-b 0.005μM R08 exp474	2.83
GSK626616 14μM R08 exp485	3.84

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C2H2 jaz
G-patch

cellular component
RNA binding