GPC4 [The Human Chemical-Genetic Interaction Map Project]

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======= GPC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPC4
  * **<color #00a2e8>Official Name</color>**: glypican 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2239|2239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75487|O75487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300168|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage.  These proteins may play a role in the control of cell division and growth regulation.  The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glypican|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of presynaptic membrane|
|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|regulation of receptor localization to synapse|
|synaptic membrane adhesion|
|regulation of protein localization to synapse|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|lysosomal lumen|
|Wnt signaling pathway, planar cell polarity pathway|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|retinoid metabolic process|
|regulation of synapse assembly|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|regulation of establishment of planar polarity|
|regulation of protein localization to cell periphery|
|terpenoid metabolic process|
|non-canonical Wnt signaling pathway|
|isoprenoid metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|regulation of morphogenesis of an epithelium|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|regulation of animal organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse|
|synapse organization|
|glutamatergic synapse|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|collagen-containing extracellular matrix|
|external side of plasma membrane|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell-cell adhesion|
|regulation of cellular protein localization|
|cell surface|
|carbohydrate derivative biosynthetic process|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell-cell signaling|
|lipid metabolic process|
|locomotion|
|organonitrogen compound biosynthetic process|
|movement of cell or subcellular component|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.23|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.88|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.546|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15348
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPC4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>