GPC4

Entrez Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

anchored component of presynaptic membrane
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
regulation of receptor localization to synapse
synaptic membrane adhesion
regulation of protein localization to synapse
regulation of presynapse assembly
regulation of presynapse organization
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Wnt signaling pathway, planar cell polarity pathway
Golgi lumen
glycosaminoglycan biosynthetic process
retinoid metabolic process
regulation of synapse assembly
aminoglycan biosynthetic process
diterpenoid metabolic process
regulation of establishment of planar polarity
regulation of protein localization to cell periphery
terpenoid metabolic process
non-canonical Wnt signaling pathway
isoprenoid metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
regulation of morphogenesis of an epithelium
regulation of protein localization to membrane
carbohydrate derivative catabolic process
regulation of synapse organization
regulation of synapse structure or activity
regulation of animal organ morphogenesis
cell-cell adhesion via plasma-membrane adhesion molecules
synapse
synapse organization
glutamatergic synapse
cell-cell signaling by wnt
Wnt signaling pathway
collagen-containing extracellular matrix
external side of plasma membrane
cell surface receptor signaling pathway involved in cell-cell signaling