GPC6 [The Human Chemical-Genetic Interaction Map Project]

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======= GPC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPC6
  * **<color #00a2e8>Official Name</color>**: glypican 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10082|10082]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y625|Q9Y625]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. {ECO:0000250, ECO:0000269|PubMed:21871017}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glypican|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|
|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|
|regulation of receptor localization to synapse|
|regulation of protein localization to synapse|
|anchored component of plasma membrane|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|lysosomal lumen|
|Wnt signaling pathway, planar cell polarity pathway|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|retinoid metabolic process|
|aminoglycan biosynthetic process|
|diterpenoid metabolic process|
|regulation of establishment of planar polarity|
|regulation of protein localization to cell periphery|
|terpenoid metabolic process|
|non-canonical Wnt signaling pathway|
|isoprenoid metabolic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|regulation of morphogenesis of an epithelium|
|regulation of protein localization to membrane|
|carbohydrate derivative catabolic process|
|regulation of animal organ morphogenesis|
|synapse|
|glutamatergic synapse|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|collagen-containing extracellular matrix|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cellular protein localization|
|cell surface|
|carbohydrate derivative biosynthetic process|
|regulation of cellular localization|
|cellular lipid metabolic process|
|cell migration|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|cell-cell signaling|
|lipid metabolic process|
|locomotion|
|organonitrogen compound biosynthetic process|
|movement of cell or subcellular component|
|extracellular space|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPC6 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>