GPC6

Entrez Summary: The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016].
UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. {ECO:0000250, ECO:0000269|PubMed:21871017}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
regulation of receptor localization to synapse
regulation of protein localization to synapse
anchored component of plasma membrane
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
Wnt signaling pathway, planar cell polarity pathway
Golgi lumen
glycosaminoglycan biosynthetic process
retinoid metabolic process
aminoglycan biosynthetic process
diterpenoid metabolic process
regulation of establishment of planar polarity
regulation of protein localization to cell periphery
terpenoid metabolic process
non-canonical Wnt signaling pathway
isoprenoid metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
regulation of morphogenesis of an epithelium
regulation of protein localization to membrane
carbohydrate derivative catabolic process
regulation of animal organ morphogenesis
synapse
glutamatergic synapse
Wnt signaling pathway
cell-cell signaling by wnt
collagen-containing extracellular matrix
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of cellular protein localization
cell surface
carbohydrate derivative biosynthetic process
regulation of cellular localization
cellular lipid metabolic process
cell migration
regulation of protein localization
carbohydrate derivative metabolic process
macromolecule catabolic process