GPD1

Entrez Summary: This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.86
TGF-beta1 44ng/ml R08 exp528	2.09

NAD Gly3P dh C
NAD Gly3P dh N

glycerol-3-phosphate dehydrogenase (quinone) activity
glycerophosphate shuttle
glycerol-3-phosphate catabolic process
glycerol-3-phosphate dehydrogenase [NAD+] activity
glycerol-3-phosphate dehydrogenase complex
NADH oxidation
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
positive regulation of glycolytic process
NADH metabolic process
NAD binding
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
gluconeogenesis
positive regulation of ATP metabolic process
positive regulation of purine nucleotide metabolic process
positive regulation of nucleotide metabolic process
NAD metabolic process
hexose biosynthetic process
monosaccharide biosynthetic process
cellular response to cAMP
cellular ketone metabolic process
primary alcohol metabolic process
positive regulation of carbohydrate metabolic process
regulation of glycolytic process
regulation of carbohydrate catabolic process
response to cAMP
respiratory electron transport chain
glucose metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
carbohydrate biosynthetic process
organophosphate catabolic process
response to organophosphorus
positive regulation of small molecule metabolic process
response to purine-containing compound
hexose metabolic process
regulation of generation of precursor metabolites and energy
cellular respiration