GPD1L [The Human Chemical-Genetic Interaction Map Project]

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======= GPD1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPD1L
  * **<color #00a2e8>Official Name</color>**: glycerol-3-phosphate dehydrogenase 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23171|23171]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N335|Q8N335]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPD1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPD1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD Gly3P dh N|
|NAD Gly3P dh C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein kinase C signaling|
|glycerol-3-phosphate catabolic process|
|glycerol-3-phosphate dehydrogenase [NAD+] activity|
|glycerol-3-phosphate dehydrogenase complex|
|NADH oxidation|
|regulation of ventricular cardiac muscle cell membrane depolarization|
|glycerol-3-phosphate metabolic process|
|alditol phosphate metabolic process|
|regulation of protein kinase C signaling|
|positive regulation of protein localization to cell surface|
|ventricular cardiac muscle cell action potential|
|negative regulation of peptidyl-serine phosphorylation|
|positive regulation of sodium ion transport|
|sodium channel regulator activity|
|NADH metabolic process|
|regulation of protein localization to cell surface|
|cardiac muscle cell action potential involved in contraction|
|NAD binding|
|phosphatidic acid biosynthetic process|
|cardiac muscle cell contraction|
|phosphatidic acid metabolic process|
|regulation of membrane depolarization|
|NAD metabolic process|
|cardiac muscle cell action potential|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|cardiac muscle contraction|
|regulation of sodium ion transport|
|heart contraction|
|actin-mediated cell contraction|
|action potential|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|ion channel binding|
|organophosphate catabolic process|
|regulation of peptidyl-serine phosphorylation|
|carbohydrate derivative catabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|regulation of heart contraction|
|phospholipid biosynthetic process|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|glycerophospholipid metabolic process|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|negative regulation of protein phosphorylation|
|regulation of membrane potential|
|negative regulation of phosphorylation|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|negative regulation of intracellular signal transduction|
|organophosphate biosynthetic process|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|actin filament-based process|
|lipid biosynthetic process|
|regulation of system process|
|negative regulation of protein modification process|
|regulation of ion transport|
|ion homeostasis|
|protein homodimerization activity|
|organophosphate metabolic process|
|regulation of cellular localization|
|cellular lipid metabolic process|
|oxidation-reduction process|
|positive regulation of transport|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|homeostatic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.71|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPD1L Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>