GPD1L

Entrez Summary: The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010].
UniProt Summary: Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 5μM R06 exp287	1.71
CVT-10216 0.1μM R06 exp278	1.96

NAD Gly3P dh N
NAD Gly3P dh C

negative regulation of protein kinase C signaling
glycerol-3-phosphate catabolic process
glycerol-3-phosphate dehydrogenase [NAD+] activity
glycerol-3-phosphate dehydrogenase complex
NADH oxidation
regulation of ventricular cardiac muscle cell membrane depolarization
glycerol-3-phosphate metabolic process
alditol phosphate metabolic process
regulation of protein kinase C signaling
positive regulation of protein localization to cell surface
ventricular cardiac muscle cell action potential
negative regulation of peptidyl-serine phosphorylation
positive regulation of sodium ion transport
sodium channel regulator activity
NADH metabolic process
regulation of protein localization to cell surface
cardiac muscle cell action potential involved in contraction
NAD binding
phosphatidic acid biosynthetic process
cardiac muscle cell contraction
phosphatidic acid metabolic process
regulation of membrane depolarization
NAD metabolic process
cardiac muscle cell action potential
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
cardiac muscle contraction
regulation of sodium ion transport
heart contraction
actin-mediated cell contraction
action potential
regulation of heart rate
heart process
striated muscle contraction
actin filament-based movement
ion channel binding
organophosphate catabolic process
regulation of peptidyl-serine phosphorylation
carbohydrate derivative catabolic process
glycerophospholipid biosynthetic process