GPKOW

Entrez Summary: This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013].
UniProt Summary: RNA-binding protein involved in pre-mRNA splicing. {ECO:0000269|PubMed:25296192}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 523/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	25/26
bone	19/26
breast	21/30
central nervous system	32/49
cervix	2/4
colorectal	12/17
esophagus	9/11
fibroblast	0/1
gastric	12/14
kidney	11/18
liver	13/19
lung	55/72
lymphocyte	11/16
ovary	21/25
pancreas	15/22
peripheral nervous system	13/15
plasma cell	9/12
prostate	1/1
skin	17/20
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	15/28
uterus	3/5

Expression Distribution

G-patch
G-patch 2

spliceosomal complex
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression