GPN2 [The Human Chemical-Genetic Interaction Map Project]

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======= GPN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPN2
  * **<color #00a2e8>Official Name</color>**: GPN-loop GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54707|54707]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9Y4|Q9H9Y4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP bind 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase activity|
|GTP binding|
|cellular component|
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.63|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.54|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.54|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.46|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.09|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.08|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.94|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.92|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.88|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.81|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.76|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.73|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.71|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.78|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg2|ALG2]]|0.503|
|[[:human genes:g:gmppb|GMPPB]]|0.485|
|[[:human genes:u:uxt|UXT]]|0.479|
|[[:human genes:w:wdr92|WDR92]]|0.474|
|[[:human genes:g:gnb1l|GNB1L]]|0.473|
|[[:human genes:m:med4|MED4]]|0.465|
|[[:human genes:r:rnmt|RNMT]]|0.464|
|[[:human genes:t:tti1|TTI1]]|0.46|
|[[:human genes:t:telo2|TELO2]]|0.459|
|[[:human genes:a:atxn10|ATXN10]]|0.458|
|[[:human genes:p:pmm2|PMM2]]|0.457|
|[[:human genes:a:alg13|ALG13]]|0.456|
|[[:human genes:m:med16|MED16]]|0.452|
|[[:human genes:r:rpp21|RPP21]]|0.45|
|[[:human genes:v:vezt|VEZT]]|0.443|
|[[:human genes:c:ccdc101|CCDC101]]|0.443|
|[[:human genes:t:thg1l|THG1L]]|0.44|
|[[:human genes:a:adsl|ADSL]]|0.438|
|[[:human genes:d:dpagt1|DPAGT1]]|0.433|
|[[:human genes:e:exoc4|EXOC4]]|0.431|
|[[:human genes:u:uhrf1|UHRF1]]|0.426|
|[[:human genes:g:gemin8|GEMIN8]]|0.425|
|[[:human genes:f:fnta|FNTA]]|0.424|
|[[:human genes:y:yars|YARS]]|0.422|
|[[:human genes:m:mis18a|MIS18A]]|0.422|
|[[:human genes:o:oip5|OIP5]]|0.409|
|[[:human genes:m:mars|MARS]]|0.409|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.407|
|[[:human genes:s:snapc5|SNAPC5]]|0.406|
|[[:human genes:m:mllt1|MLLT1]]|0.404|
|[[:human genes:g:gfpt1|GFPT1]]|0.402|
|[[:human genes:t:tti2|TTI2]]|0.401|
|[[:human genes:g:gemin5|GEMIN5]]|0.401|
|[[:human genes:d:ddost|DDOST]]|0.4|
|[[:human genes:h:haus8|HAUS8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 65
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPN2 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>