GPN2 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: GPN2
Official Name: GPN-loop GTPase 2
Aliases and Previous Symbols: N/A
Entrez ID: 54707
UniProt: Q9H9Y4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-2536 0.001μM R01 exp41	-2.63
Ribavirin 10μM R01 exp52	-2.54
Taxol 0.002μM R01 exp54	-2.54
Mubritinib 0.2μM R01 exp48	-2.46
BI-6727 0.001μM R01 exp42	-2.09
Alpha-Amanitin 0.5μM R00 exp5	-2.08
UM131593 0.1μM R01 exp58	-1.94
Docetaxel 0.002μM R01 exp45	-1.92
2-Methoxyestradiol 0.2μM R01 exp40	-1.88
HMS-I2 10μM R06 exp288	-1.88
Nifuroxazide 1μM R01 exp51	-1.84
HMS-I1 1μM R01 exp46	-1.81
Campthothecin 0.001μM R06 exp270	-1.76
Ribavirin 10 to 15μM on day4 R04 exp160	-1.73
Lapatinib 5μM R01 exp47	-1.71
DABN 20μM R00 exp17	1.78
Vitamin-D3 40μM R08 exp536	1.98

Gene	Correlation
ALG2	0.503
GMPPB	0.485
UXT	0.479
WDR92	0.474
GNB1L	0.473
MED4	0.465
RNMT	0.464
TTI1	0.46
TELO2	0.459
ATXN10	0.458
PMM2	0.457
ALG13	0.456
MED16	0.452
RPP21	0.45
VEZT	0.443
CCDC101	0.443
THG1L	0.44
ADSL	0.438
DPAGT1	0.433
EXOC4	0.431
UHRF1	0.426
GEMIN8	0.425
FNTA	0.424
YARS	0.422
MIS18A	0.422
OIP5	0.409
MARS	0.409
GTF3C3	0.407
SNAPC5	0.406
MLLT1	0.404
GFPT1	0.402
TTI2	0.401
GEMIN5	0.401
DDOST	0.4
HAUS8	0.4

Global Fraction of Cell Lines Where Essential: 734/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 65
Expression level (log2 read counts): 5.83

Expression Distribution

Last modified: 2026/01/07 22:36
by 127.0.0.1